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Phenibut is a close structural analogue of GABA, as well as of baclofen (β-(4-chlorophenyl)-GABA), pregabalin (β-isobutyl-GABA), and GABOB (β-hydroxy-GABA).[8] Originally thought to act as a selective GABAB receptor agonist, phenibut has since been found to act preferentially as a blocker of α2δ subunit-containing voltage-gated


 calcium channels, similarly to gabapentin and pregabalin.[9][10] As such, by definition, phenibut is a gabapentinoid

1963, St.Petersburg, Russia – A Soviet Union lab scientist by the name of Perekalin synthesizes 3-phenyl-4-aminobutyric acid, an experimental drug intended to calm psychiatric children.

1964 – Professor Khaunma labels the drug Phenigamma and reports the first findings of its tranquilizing effects in the Byulleten Eksperimental’noi Biologii i Meditsiny.

1975 – Phenigamma has spread from clinical practice to public use under the name of Phenibut. The Soviet Ministry mandates its use for astronauts in space flights due to the drug’s revolutionary psychologically calming yet cognitively stimulating effects.

2001 – Over 300 scientific publications have studied Phenibut’s nootropic and pharmacological properties.

2014 – Phenibut is used all over the globe as a smart drug, mood enhancer, sleep aid and recovery booster.

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Phenibut Effects

The primary reason individuals take Phenibut is for its ability to promote relaxation.* However, that is not the only benefit. Aside from its potential as a nootropic, this product can also support a healthy mood and promote sleep.

Promoting Relaxation

Phenibut is able to promote relaxation without drowsiness. Because of this, Russian cosmonauts often used Phenibut. Phenibut allowed them to work in less than ideal conditions without succumbing to the effects of mood imbalance.

Nootropic Benefits

There is some debate as to whether this product is a true nootropic. However, there is some evidence of its ability to enhance cognition. In passive avoidance tasks, Phenibut showed enhanced learning and memory. It also enhanced the performance of mice during swimming and rotating rod tests.


During a forced swim test, Phenibut reduced immobility time to a significant degree. Scientists use forced swim tests to measure activity related to enhanced mood.

Sleep Quality

This compound provides sleep benefits as well. One study suggests this is because it may activate dopaminergic processes which cause sedation.

Warnings: Individuals should not take this product on a daily basis. Tolerance develops rapidly with repeated use. When taken in excessive frequency, Phenibut can cause withdrawal symptoms upon cessation of use. To avoid this, follow proper dosing instructions. Individuals taking MAOIs should not take this product. Do not take this powder with alcohol. Recommended Dosage Individuals should start with 250mg. Some individuals use larger doses, but you should never exceed 1.5g. Individuals should cycle Phenibut.